cd47 peptide CD47 peptide - Minimal self peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles CD47 is a ubiquitously present transmembrane immunoglobulin molecule The Promising Role of CD47 Peptides in Cancer Immunotherapy

Peptide-functionalized lipid nanoparticles for targeted systemic mRNA delivery to the brain The CD47 peptide is emerging as a significant player in the field of cancer immunotherapy, offering novel strategies to overcome tumor immune evasion and enhance therapeutic outcomes. CD47, also known as Cluster of Differentiation 47 or integrin associated protein (IAP), is a transmembrane protein ubiquitously present on human cells.作者：B Li·2023·被引用次数：7—CD47/SIRPα pathwayis a new breakthrough in the field of tumor immunity after PD-1/PD-L1. While current monoclonal antibody therapies ... Its primary role in the context of cancer is its function as a "don't eat me" signal. When CD47 is overexpressed on tumor cells, it interacts with SIRPα (Signal Regulatory Protein alpha) on macrophages, effectively inhibiting phagocytosis and allowing cancer cells to escape destruction by the immune system. This interaction is a critical mechanism contributing to immune evasion in various cancers.

Researchers are actively exploring various peptide-based approaches to disrupt this detrimental CD47/SIRPα pathway.CD47:Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in ... One prominent area of investigation involves the development of CD47 peptide-cloaked nanocarriers. For instance, peptide-cloaked lipid nanoparticles (LNPs) have demonstrated the ability to deliver mRNA therapeutics while simultaneously incorporating a "don't eat me" CD47 signal. This innovative modification has shown that CD47 modification decreased macrophage and hepatic uptake both in vitro and in vivo, suggesting a way to improve the targeted delivery and efficacy of these nanocarriers.CD47 peptide-albumin cloaked mesoporous silica ... Studies have indicated that the impact of CD47 peptide on LNP uptake is largely mediated through the CD47-SIRP-α interaction.

Beyond nanocarrier cloaking, researchers are designing peptides that directly target and block the CD47/SIRPα interaction. These CD47 blocking peptides are being developed to restore the immune system's ability to recognize and eliminate cancer cells.Design of a novel chimeric peptide via dual blockade of CD47 ... For example, novel CD47-blocking peptides like VK17 have been identified, with potential for fusion to other therapeutic molecules to create synergistic effects.CD47 Blocking Peptide. Product no.: P-CD47. CD47 Blocking Peptide. 5.00 * · Shipping Options · Bulk and Special Orders Quote. Description ... The development of macrocyclic peptides that bind to SIRPα and efficiently block its interaction with CD47 is another promising avenue, as demonstrated by research showing these peptides can effectively block the CD47/SIRPα interactionCD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP)is a transmembrane proteinthat in humans is encoded by the CD47 gene..

Furthermore, the concept of in-situ peptide-antibody self-assembly to block CD47 and CD24 signaling is being investigated. This approach aims to enhance the phagocytic ability of macrophages, leading to improved anti-tumor responses. The identification of anti-CD47 peptides that can block the CD47/SIRPα interaction positions them as potential candidates for cancer immunotherapy.CD47 (Cluster of Differentiation 47) - PMC - NIH These peptides can be derived from various sources, including the C-terminal domain of thrombospondin-1, and have shown efficacy in efficiently killing malignant CLL B cells.作者：W Zhang·2024·被引用次数：44—By simultaneously blocking CD47 and CD24 signaling,PAC-SABI enhances the phagocytic ability of macrophagesin vitro and in vivo, promoting anti ...

The overexpression of CD47 is a common feature in many cancers, including acute myeloid leukemia, where CD47 expression can vary. This overexpression enables cancer cells to evade phagocytosis, making CD47 a crucial target for therapeutic intervention. Strategies like using PAP NPs that can self-assemble to form fibrous networks and anchor CD47 on the surface of tumor cells are being explored to promote their recognition and phagocytosis by macrophages.CD47 (Cluster of Differentiation 47) - PMC - NIH

The scientific community is actively exploring different types of peptides for this purposeCD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.. This includes a 21-amino-acid peptide that serves as a cornerstone for researchers studying the interplay between tumor cells and the immune system, as well as synthetic peptides designed for use in combination with anti-CD47 antibodies to potentially block antibody binding to its target protein. The overarching goal is to break the "don't eat me" signal.

In summary, the CD47 peptide represents a significant advancement in the development of targeted cancer therapies作者：J Lin·被引用次数：6—CD47plays a critical role in inhibiting macrophage phagocytosis and promoting tumor immune escape. Given the promising results of RS17-M6P3- .... By interfering with the CD47/SIRPα pathway, these peptides can restore macrophage-mediated phagocytosis, thereby promoting anti-tumor immunity. The ongoing research into CD47 modification decreased macrophage and hepatic uptake, the development of PAC-SABI which enhances the phagocytic ability of macrophages, and the identification of novel CD47-blocking peptides underscore the immense potential of CD47 peptide-based strategies in the fight against cancer. The CD47/SIRPα pathway is recognized as a new breakthrough in tumor immunity, offering a promising alternative to existing therapies like PD-1/PD-L1 blockade作者：L Pan·2023·被引用次数：4—In this study, we identified anovel CD47-blocking peptide VK17by phage display technique. A pro-apoptotic VK30 peptide was obtained after VK17 was fused to ....