cd47 peptide-cloaked lipid nanoparticles promote cell-specific mrna delivery lipid nanoparticle - cecred-peptide-serum nanoparticles CD47 Peptide-Cloaked Lipid Nanoparticles Promote Cell-Specific mRNA Delivery

ccp-peptide Lipid nanoparticles (LNPs) have revolutionized the field of therapeutics, particularly with the advent of mRNA-based therapeutics delivered via lipid nano platforms. These nanoparticles offer a powerful mechanism for delivering genetic material to target cells, opening doors for treating a wide range of diseases. However, achieving precise cell-specific mRNA delivery remains a critical challenge.作者：N Abbrederis·2025—CD47 peptide-cloaked lipid nanoparticles promote cell-specific mRNA delivery. Mol. Ther. (2025). J. Qin. RGD peptide-based lipids for targeted mRNA delivery ... This is where innovative strategies, such as cloaking lipid nanoparticles with specific peptides, come into playCD47 peptide-cloaked lipid nanoparticles promote ....

One such groundbreaking approach involves the use of CD47 peptide-cloaked lipid nanoparticles. The CD47 protein, often referred to as the "don't eat me" signal, plays a crucial role in cell-cell interactions and immune evasion. By integrating a CD47 peptide onto the surface of lipid nanoparticles, researchers have demonstrated a significant improvement in directing these nanocarriers to specific cell types while minimizing unwanted uptake by other cells, particularly macrophagesCD47 peptide-cloaked lipid nanoparticles promote cell-specific mRNA delivery. Mol. Ther. (2025), pp. 3195-3208. View PDFView articleView in Scopus Google .... This modification effectively reduces macrophage clearance, a common hurdle in systemic delivery of therapeutic agents.作者：TE Papp·2025·被引用次数：19—We showed thatCD47modification decreased macrophage and hepatic uptake both in vitro and in vivo. CombiningCD47modification with antibodies ...

The efficacy of CD47 peptide-cloaked lipid nanoparticles in promoting cell-specific mRNA delivery has been highlighted in recent research. These studies show that the CD47 modification decreases uptake by macrophages and hepatic cells, both *in vitro* and *in vivo*. This targeted approach ensures that the mRNA payload reaches its intended destination more efficiently, thereby enhancing therapeutic outcomes2025年10月27日—mRNA-based therapeutics formulated inlipid nanoparticles(mRNA-LNPs) have emerged as a groundbreaking platform technology for vaccination, .... The peptide acts as a crucial modulator, imparting stealth properties to the nanoparticle against phagocytic cells.

Furthermore, the development of these advanced lipid nanoparticle systems is not limited to CD47Our validated LNPdeliverysystem enables reliable genedeliveryto a range ofcelltypes—including Tcells, NKcells, macrophages, dendritic .... Researchers are exploring various surface modifications, including other receptor-specific ligands, to further refine targeting capabilities作者：TE Papp·被引用次数：19—Lipid nanoparticleencapsulating messenger RNA (LNP-mRNA) has emerged as a promising tool for therapeutic genedeliveryin applica- tions such .... For instance, some LNPs were designed for delivering reporter DNA plasmid or mRNA into specific cellular models, showcasing the versatility of this technology作者：X Xu·2025·被引用次数：1—CD47 peptide-cloaked lipid nanoparticles promote cell-specific mRNA delivery. Mol Ther, 33 (2025), pp. 3195-3208. Google Scholar. 213. R. Münter .... The ability to engineer nanoparticles for precise cell delivery is paramount for the success of mRNA delivery strategies.作者：S Qin·2025·被引用次数：3—This platform utilized aCD47-derived self-peptide(SP) to confer a “don't-eat-me” signal, thereby minimizing systemic macrophage clearance and prolonging ...

The implications of CD47 peptide-cloaked lipid nanoparticles extend to diverse applications. This technology has the potential to transform the landscape of mRNA-based therapeutics, enabling more effective treatment strategies for various conditions.LNP Delivery System for mRNA The precise control over delivery offered by these cloaked lipid nanoparticles is a significant step forward, promising to unlock the full potential of mRNA as a therapeutic modality作者：AJDS Sanchez·2023·被引用次数：47—CD47 peptide-cloaked lipid nanoparticles promote cell-specific mRNA delivery. Molecular Therapy, Volume 33, Issue 7, 2025, pp. 3195-3208. Tyler Ellis Papp .... This advancement is crucial for developing next-generation therapies that are both safe and highly effective.RGD peptide-based lipids for targeted mRNA delivery and ... The integration of a CD47 peptide is a key innovation that enhances the specificity and bioavailability of mRNA delivery systems.Deciphering the biological fate of mRNA-LNP-based ...