p113 peptide peptide - P113漱 口水 P113 peptide The Multifaceted Role of the P113 Peptide in Oral Health and Beyond

P113+ mouthwash The p113 peptide has emerged as a significant area of research, particularly for its potent antimicrobial properties and its diverse applications, especially in oral care. Derived from histatin 5, a naturally occurring human salivary protein, P-113 is a histidine-rich antimicrobial peptide (AMP) that demonstrates broad-spectrum activity against a range of clinically relevant microorganisms. This peptide holds considerable promise for revolutionizing oral hygiene products and potentially addressing various health concerns.

Understanding the P113 Peptide

P113 peptide is a relatively short peptide chain, typically consisting of 12 amino acids.P113+十二胜肽成份是由美國波士頓大學教授所發現的一段生物活性胜肽，源於人體抗菌蛋白，並在美國、加拿大及歐洲各國取得22項專利，該成份能有效抑制造成私密處搔癢及白帶 ... Its sequence, often represented as AKRHHGYKRKFH, is crucial to its functional capabilities. This peptide is known for its ability to selectively inhibit the growth of harmful bacteria and fungi without negatively impacting beneficial microorganisms or host cells. This selectivity is a key advantage, differentiating it from traditional antibiotics.2026年1月7日—In addition, decreased dental plaque weight, dental plaque index, and gingival index were all observed in the experimental group. Conclusion The ...

The research into p113 peptide has explored various modifications and derivatives.Antimicrobial Peptide P-113-DPS Suppresses the ... One notable example is Nal-P-113, a modified antimicrobial peptide where histidine residues are replaced with β-naphthylalanine. This modification has shown to enhance salt resistance, although it may have limited efficacy against certain molecules like LPS作者：ZM Wu·2017·被引用次数：15—In this study, bifunctionalP-113 peptides2–5 were designed as Sortase A substrates and synthesized by solid support peptide synthesis, where the N-terminus .... Another significant development is P113+, which has undergone extensive research and clinical trialsHigh yield synthesis of cyclic analogues of antibacterial .... P113+ has been recognized for its highly inhibitory activity against bacteria and has successfully passed Phase II clinical trials with the US FDA. This advanced form of the p113 peptide has also secured multiple international patents, highlighting its innovative nature and commercial potential.

Applications in Oral Health

The most extensively studied application of the p113 peptide is in oral health唾液中神奇的抗菌蛋白：P113+通過二期臨床試驗 - 微笑藥師網. Its ability to combat cariogenic bacteria, such as *Streptococcus mutans* (S.知名藝人王思平真心推薦. 重大發現.Peptide+113次實驗發現=P113⁺; 源於人體口腔天然免疫蛋白; 具有高度抗菌活性的氨基酸片段. 科學驗證. 臨床實驗超過800例; 低致敏性、無細胞毒性; 對人體即口腔黏膜不具刺激性.P113⁺ 獨家專利活性肽.P113⁺後續生產使用胜肽合成(PeptideSynthesis)技術.P113⁺ 獨家專利活性肽. mutans), makes it an ideal ingredient for oral hygiene products.Antimicrobial peptides - ScienceDirect Studies have demonstrated that P-113-DPS, a specific formulation, effectively suppresses the growth and viability of *S. mutans*, reducing its acidogenicity and aciduricity. This directly translates to a potential reduction in dental caries.

Furthermore, research indicates that p113 peptide can significantly reduce the number of oral bacteria and inhibit dental plaque formation.P-113 (from histatin 5) peptide Clinical assessments have shown decreased dental plaque weight, dental plaque index, and gingival index in groups using p113 peptide-based products. This suggests a substantial benefit in preventing and managing periodontal disease作者：H Wang·2017·被引用次数：45—Conclusions. Nal-P-113exhibited protective effects on Porphyromonas gingivalis-induced periodontitis in rats by limiting the amount of bacteria and modulating IL-1β and TNF-α production. The use of Nal-P-113in vivo might serve as a beneficial preventive or therapeutic approach for periodontitis.. The p113 peptide is thus being incorporated into novel oral health care products, including P113+ mouthwash and P113 mouth wash, offering a fluoride-free alternative that effectively reduces oral pathogens. The oral health care benefits extend to maintaining the balance of oral microflora, contributing to overall oral health作者：H Wang·2018·被引用次数：55—Nal-P-113, a modified antimicrobialpeptide, specifically replaces the histidine residues ofP-113with the bulky amino acid β-naphthylalanine, ....

Broader Antimicrobial and Therapeutic Potential

Beyond oral health, the p113 peptide and its derivatives show promise in other therapeutic areas. Its broad-spectrum antimicrobial activity extends to fighting fungi like *Candida albicans*.Efficacy of antimicrobialpeptide P113oral health care products on the reduction of oral bacteria number and dental plaque formation in a randomized clinical ... Research using solution nuclear magnetic resonance (NMR) methods has begun to elucidate the molecular mechanisms behind these interactions.

The therapeutic potential of modified peptides like Nal-P-113 is also being explored for conditions such as periodontitis.High Level Expression and Purification of the Clinically ... Studies in animal models have shown that Nal-P-113 can limit bacterial load and modulate inflammatory responses (IL-1β and TNF-α), suggesting a role in preventing and treating periodontal disease. The development of antimicrobial peptide hydrogels incorporating P-113 is another avenue being investigated for targeted drug delivery and enhanced therapeutic effects.

Scientific Validation and Future Directions

The efficacy and safety of the p113 peptide are supported by a growing body of scientific evidence. Numerous publications detail research into its synthesis, biological activity, and clinical applications. The p113 peptide has undergone rigorous testing, including clinical trials, and has demonstrated a low level of toxicity and minimal adverse reactions. The fact that P113+ has passed US FDA clinical phase II trial is a significant indicator of its safety and potential therapeutic valueThe P-113 Fragment of Histatin 5 Requires a Specific Peptide ....

The ongoing research into p113 peptide focuses on optimizing its delivery, enhancing its stability, and exploring novel applications. From peptide synthesis techniques to the development of advanced formulations like nanoparticle-based delivery systems, the scientific community is actively working to harness the full potential of this remarkable peptide.P‐113 Peptide: New experimental evidences on its ... The exploration of peptides in general, and specifically P-113 peptides, continues to reveal new possibilities in the fight against microbial infections and the promotion of health. The P-113 sequence, and its variations, represent a significant advancement in the field of antimicrobial peptides, offering a promising future for both preventative and therapeutic interventions.