peptide 257 OVA Peptide(257-264 - HAPeptide Peptide Understanding Peptide 257: An In-Depth Look at OVA Peptide (257-264)

HAPeptide The term "peptide 257" often refers to a specific and highly studied peptide fragment derived from ovalbumin (OVA), a major protein found in egg white. This particular peptide, known as OVA Peptide (257-264), plays a significant role in immunological research due to its function as a class I (Kb)-restricted peptide epitope of OVAThis is aclass I (Kb)-restricted peptide epitope of OVA, an octameric peptide from ovalbumin presented by the class I MHC molecule, H-2Kb.. Understanding this peptide requires delving into its structure, presentation, and applications in scientific investigations.

The Structure and Presentation of OVA Peptide (257-264)

OVA Peptide (257-264) is an octameric peptide, meaning it is composed of eight amino acids.OVA (257-264) is a class I (Kb)-restricted peptide epitope of OVA, an octameric peptide from ovalbumin presented by the class I MHC molecule, H-2Kb. Its specific sequence is SIINFEKL. This sequence is not arbitrary; it represents a crucial part of the ovalbumin protein that is recognized by the immune system, specifically by T cells.

The presentation of this peptide to the immune system is mediated by MHC class I molecules. In particular, OVA Peptide (257-264) is presented by the H-2Kb molecule, which is a specific type of class I MHC molecule. This binding to H-2Kb is what makes it a class I (Kb)-restricted peptide epitope. This restriction is vital because it dictates which immune cells can recognize the peptide and initiate an immune responseOva peptide (257-264) | C45H74N10O13 | CID 22134157 - structure, chemical names, physical and chemical properties, classification, patents, literature, .... The H-2Kb molecule, found on the surface of many cells, displays intracellularly produced peptides to cytotoxic T lymphocytes (CTLs), also known as CD8+ T cells.

Key Characteristics and Properties:

* Sequence: Ser-Ile-Ile-Asn-Phe-Glu-Lys-Leu (SIINFEKL)

* Molecular Formula: C45H74N10O13

* CAS Numbers: Commonly associated with CAS No. 1262751-08-5 and 138831-86-4.OVA (257-264) Peptide Fragment

* Form: Often supplied as OVA Peptide (257-264) TFA, where TFA (trifluoroacetic acid) is used for purification and stabilization.

* Origin: Derived from ovalbumin, the main protein in egg white.

Significance in Immunological Research

The primary utility of OVA Peptide (257-264) lies in its well-defined immunogenic properties, making it an invaluable tool for studying various aspects of cellular immunity.SIINFEKL sequence.OVA Peptide (257-264) is a fragment of the OVA protein that stimulates an antibody response. It has been shown to activate various types ...

* T-Cell Activation: OVA Peptide (257-264) is extensively used to stimulate T cells, particularly CD8+ T cells. This stimulation can lead to the proliferation and activation of cytotoxic T lymphocytes (CTLs), which are crucial for eliminating infected or cancerous cells. Researchers utilize this peptide to induce an immune response in animal models, allowing them to study the mechanisms of T-cell mediated immunity.

* Immunotherapy and Vaccine Development: The ability of OVA Peptide (257-264) to elicit a strong immune response makes it a candidate for use in developing immunotherapeutic vaccines. It can be employed to test the efficacy of new adjuvants, which are substances that enhance the immune response to an antigen.OVA257-264 (SIINFEKL) peptide bound to H-2Kb ... The OVA 257-264 scrambled (FILKSINE) variant is also used in such studies, providing a control to understand the specificity of the immune response.

* Understanding Antigen Presentation: As a model antigen, OVA Peptide (257-264) is instrumental in understanding how antigens are processed and presented by MHC class I molecules. Studies involving this ovalbumin-derived peptide help elucidate the interactions between peptides and MHC molecules, as well as the subsequent activation of T-cell receptorsOVA Peptide (257-264). The 25-D1.OVA 257-264 scrambled (FILKSINE)16 monoclonal antibody, for instance, is known to react specifically with the ovalbumin-derived peptide SIINFEKL bound to H-2Kb, highlighting its utility in specific immunological assays.OVA Peptide 257-264 2TFA

* Research-Grade Applications: Research-grade Ova 257 264 Peptide is readily available for various metabolic research studies and is a common component in peptide catalogs and peptide shops onlineOVA Peptide (257-264),1mg. It is also offered by various suppliers as a peptide fragment or antigen peptide, often in quantities of 1 mg or more.

Variations and Related Concepts

While OVA Peptide (257-264) is the most commonly referenced, variations exist. For example, OVA-G4 Peptide is a variant with the sequence SIIGFEKL, demonstrating how minor changes can affect peptide-antigen interactions.Research-grade Ova 257 264 Peptideavailable for metabolic research studies. Fast shipping, competitive prices. Showing 1 to 9 of 9 products. The broader concept of peptides encompasses a vast array of molecules with diverse functions, including those used in skincare for their purported skin-repairing benefits, though the peptide 257 discussed here is distinct from cosmetic peptides.

In summary, peptide 257, specifically OVA Peptide (257-264), is a well-characterized and essential tool in immunology. Its role as a class I (Kb)-restricted peptide epitope of OVA presented by the H-2Kb molecule makes it a critical component for research into T-cell immunity, vaccine development, and antigen presentation mechanismsOVA 257-264 (SIINFEKL) is a well-characterized, immunodominant epitope derived from chicken ovalbumin protein (Uniprot P01012).. Its availability as a research-grade Ova 257 264 Peptide ensures its continued use in advancing scientific understanding.OVA Peptide(257-264) TFA是OVA 的I 类(Kb)-限制性肽表位，它是一种八聚体肽，可以来自I 类MHC 分子H-2Kb 所呈现的卵清蛋白。 MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务. Custom Peptide Synthesis. OVA Peptide(257-264) TFA. OVA Peptide(257-264) TFA Chemical Structure. CAS No. : 1262751-08-5.